{"hq_id":"hq-c-org-000574","name":"N-Methyl-2-pyrrolidone (NMP)","context":"human_adult","timestamp":"2026-08-28T02:44:31.466Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"nmp_reach_2020","type":"regulatory","title":"NMP N-Methyl-2-Pyrrolidone 1-Methyl-2-Pyrrolidinone; Li-Ion Battery Cathode PVDF Slurry Solvent Gigafactory; REACH Annex XVII Entry 71 WEC 10 mg/m3 Consumer 0.3% Restriction; SVHC Repr 1B H360D Candidate List; Embryolethality Reduced Birth Weight Rat Rabbit; Danish Semiconductor Cohort Spontaneous Abortion; Metabolic Activation 5-HNMP HMSI Biological Monitoring; ICH Q3C Class 2 PDE 53 mg/day Pharmaceutical; Water-Based CMC/SBR Binder Alternative; IARC Not Evaluated Not Carcinogen","year":2020},{"id":"epa_tsca_nmp_risk_evaluation_2020","type":"regulatory","title":"EPA TSCA Risk Evaluation for N-Methylpyrrolidone (NMP) — repro-tox unreasonable risk","year":2020},{"id":"solomon_nmp_cleanroom_repro_2002","type":"primary_literature","title":"Solomon et al. — semiconductor cleanroom-worker pregnancy-loss cohort (NMP and EGEs)","year":2002},{"id":"ipcs_icsc_nmp","type":"report","title":"IPCS/ILO International Chemical Safety Card (ICSC 0513) — N-Methyl-2-pyrrolidone","url":"https://inchem.org/documents/icsc/icsc/eics0513.htm"}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — n-meth","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:IARC:not evaluated by iarc for carcinogenicity — n-meth","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}