{"hq_id":"hq-c-org-000573","name":"Dimethylformamide (DMF)","context":"human_adult","timestamp":"2026-08-28T02:50:36.857Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.703698,"weightedMean":0.703698,"std_dev":0.06843,"confidence_interval_95":[0.7,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2014,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2014,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2014,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2014,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2014,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.5438,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dmf_vol110_2014","type":"regulatory","title":"IARC Group 2A DMF Dimethylformamide Vol 110 2014; Testicular Germ Cell Tumor TGCT Shoe Manufacture Acrylic Fiber Workers Italy Czech Republic; CYP2E1 Metabolic Activation MMF Monomethylformamide; Hepatotoxicity Monday Morning Syndrome Alcohol CYP2E1 Induction; EU CLP Repr 1B H360D SVHC REACH Candidate List; ACGIH TLV 5 ppm Skin Notation Dermal Absorption; PU Leather Spandex Kevlar Membrane Casting; ICH Q3C Class 2 PDE 8.8 mg/day Pharmaceutical; Biological Monitoring Urinary MMF DMAC","year":2014},{"id":"ipcs_icsc_dmf","type":"report","title":"IPCS/ILO International Chemical Safety Card (ICSC 0457) — N,N-Dimethylformamide","url":"https://inchem.org/documents/icsc/icsc/eics0457.htm"},{"id":"osha_dmf_pel","type":"regulatory","title":"OSHA PEL — N,N-Dimethylformamide (29 CFR 1910.1000) 10 ppm TWA, skin notation","year":1989},{"id":"niosh_dmf_synthetic_leather","type":"primary_literature","title":"NIOSH cohort — synthetic-leather DMF-exposed workers (testicular cancer + hepatotoxicity)","year":1989}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}