{"hq_id":"hq-c-org-000567","name":"Chromium(III) sulfate (tanning agent)","context":"human_adult","timestamp":"2026-09-10T09:50:31.431Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.273026,"weightedMean":0.273026,"std_dev":0.024922,"confidence_interval_95":[0.25,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35},{"source":"IARC","year":2012,"value":0.25,"weight":0.41}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.833853,"disagreement_magnitude":0.307831,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. HQ_DIRECT classifies as higher risk (30th percentile), while IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_criii_2012","type":"regulatory","title":"IARC Monographs Volume 49 1990 Volume 100C 2012 Chromium(III) Compounds Group 3; Cr(VI) IARC Group 1 Distinction; Chrome Tanning 80% Global Leather Production; EU Regulation 301/2014 Cr(VI) 3 mg/kg Leather Limit; Chrome Allergy Type IV Dermatitis 3-4% Prevalence; Cr(III)-to-Cr(VI) Oxidation UV Alkaline Microbial; Tannery Wastewater Chromium Pollution; UK WEL 0.5 mg/m3 Cr(III); EU CLP Aquatic Chronic 3","year":2012}],"sources_scope":"record","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":36,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}