{"hq_id":"hq-c-org-000564","name":"Afoxolaner (NexGard)","context":"human_adult","timestamp":"2026-08-28T02:51:18.933Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"cvm_fda_afoxolaner_2022","type":"regulatory","title":"Afoxolaner NexGard Boehringer Ingelheim FDA CVM 2013; Isoxazoline GABA Chloride Channel Dog Only Monthly; FDA 2018 Class Neurological Warning Tremors Ataxia Seizures; Half-Life 14-15 Days CYP3A4 Hepatic; Beef-Flavored Chewable Flea Tick Ixodes Dermacentor Amblyomma; Post-Marketing Pharmacovigilance; EMA EU Approved; IARC Not Evaluated; Aquatic EMA VMP Assessment; NexGard Spectra Milbemycin Combination","year":2022}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc — afoxolaner (nexgard; boehr","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":34,"warnings":["unmapped_classification:IARC:not evaluated by iarc — afoxolaner (nexgard; boehr"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}