{"hq_id":"hq-c-org-000563","name":"Fluralaner (Bravecto)","context":"human_adult","timestamp":"2026-08-28T02:51:19.207Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"cvm_fda_fluralaner_2022","type":"regulatory","title":"Fluralaner Bravecto MSD Animal Health FDA CVM; Isoxazoline GABA Chloride Channel Antagonist; 12-Week Duration Single Dose; FDA Neurological Adverse Event Warning 2018 2022 Tremors Ataxia Seizures; GABA-A Invertebrate Selectivity; Long Half-Life 12-15 Days Lipophilic Adipose; Bravecto Chewable Spot-On; Pharmacovigilance Post-Marketing; Aquatic Invertebrate Daphnia Ecotoxicity; IARC Not Evaluated","year":2022}],"sources_scope":"record","warnings":["unmapped_classification:IARC:not evaluated by iarc — fluralaner (bravecto; msd ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":36,"warnings":["unmapped_classification:IARC:not evaluated by iarc — fluralaner (bravecto; msd "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}