{"hq_id":"hq-c-org-000554","name":"Diphenylamine (DPA)","context":"human_adult","timestamp":"2026-10-27T17:01:32.892Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000554","sha256":"182d65eacd6f167164776d30730459240cb51786a8e945f5c185f49e408214b5"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.361842,"weightedMean":0.361842,"std_dev":0.149532,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"IARC","year":2022,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2022,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2022,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2022,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2022,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.00312,"disagreement_magnitude":0.335052,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_dpa_1987","type":"regulatory","title":"IARC Monographs Volume 16 1978 Supplement 7 1987 diphenylamine evaluation, superseded by Volume 130 (2021 evaluation); Apple Postharvest Scald Inhibitor; Rubber Antiozonant Antioxidant Tire ADPA; Smokeless Powder Propellant Stabilizer; EU CLP Aquatic Acute 1 H400 Chronic 1 H410; N-Nitrosodiphenylamine Nitrosamine Formation; ACGIH TLV-TWA 10 mg/m3; Azo Dye Intermediate (1987)","year":1987},{"id":"iarc_130_diphenylamine","type":"regulatory","title":"IARC Monographs Volume 130: Anthracene, 2-Bromopropane, Butyl Methacrylate, and Dimethyl Hydrogen Phosphite (and other agents) — Diphenylamine Group 2B (2021 evaluation, published 2022)","year":2022},{"id":"r60-2026-09-27-d899-iris-landing-48-diphenylamine","type":"regulatory","title":"Diphenylamine | CASRN 122-39-4 | DTXSID4021975 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=48"},{"id":"r60-2026-09-29-d899-s1-b05-niosh-npg-nengapdxg-appendix-g","type":"regulatory","title":"Air Contaminants Update Project | NIOSH | CDC","url":"https://www.cdc.gov/niosh/npg/nengapdxg.html"},{"id":"r60-2026-09-30-d899-s1-b11-niosh-npg-npgd0240-diphenylamine","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Diphenylamine","url":"https://www.cdc.gov/niosh/npg/npgd0240.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-28-d899-s4-b04-epa-hhbp-2021","type":"regulatory","title":"2021 Human Health Benchmarks for Pesticides | US EPA","url":"https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides"},{"id":"r60-2026-09-28-d449-fr-E6-20648-71FR70703-raw","type":"regulatory","title":"Diphenylamine; Proposed Pesticide Tolerance","url":"https://www.federalregister.gov/documents/full_text/text/2006/12/06/E6-20648.txt"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_11487","type":"pubchem","title":"PubChem: Toxicity section (CID 11487)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/11487/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-09-28-d899-s3-b03-cellar-02005R0396-20260819-fmx4-en-live-text","type":"regulatory","title":"Regulation (EC) No 396/2005 of the European Parliament and of the Council of 23 February 2005 on maximum residue levels of pesticides in or on food and feed of plant and animal origin and amending Council Directive 91/414/EEC (Text with EEA relevance)","url":"https://publications.europa.eu/resource/celex/02005R0396-20260819"},{"id":"doc-2026-10-03-d975-cfpub-epa-gov-ncea-pprtv-documents-diphenylamine-pdf","type":"assessment","title":"Provisional Peer-Reviewed Toxicity Values for Diphenylamine (CASRN 122-39-4), EPA/690/R-11/026F, Final, 5-11-2011","url":"https://cfpub.epa.gov/ncea/pprtv/documents/Diphenylamine.pdf"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-11487","type":"database","title":"PubChem computed properties for CID 11487 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/11487"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-11487","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 11487; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/11487/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-11487","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 11487; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/11487/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-11487","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 11487; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/11487/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid4021975","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4021975 (Diphenylamine (DPA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4021975"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-11487","type":"database","title":"PubChem computed structure descriptors for CID 11487 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/11487"},{"id":"r60-2026-10-03-d972-epa-opp-evaluating-pesticides-carcinogenic-potential","type":"regulatory","title":"Evaluating Pesticides for Carcinogenic Potential | US EPA","url":"https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/evaluating-pesticides-carcinogenic-potential"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":51,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}