{"hq_id":"hq-c-org-000554","name":"Diphenylamine (DPA)","context":"human_adult","timestamp":"2026-08-28T01:29:15.871Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.301635,"weightedMean":0.301635,"std_dev":0.158539,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"IARC","year":2022,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.15,"weight":0.30176}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2022,"value":0.82,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2022,"value":0.5,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2022,"value":1,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2022,"value":0.75,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.335052,"warning":null},"outliers":[{"source":"IARC","value":0.5}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while EPA CTX / EPA OPP concludes lower risk (15th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dpa_1987","type":"regulatory","title":"IARC Monographs Volume 16 1978 Supplement 7 1987 diphenylamine evaluation, superseded by Volume 130 (2021 evaluation); Apple Postharvest Scald Inhibitor EFSA 2012 EU MRL 0.1 mg/kg; Rubber Antiozonant Antioxidant Tire ADPA; Smokeless Powder Propellant Stabilizer; EU CLP Aquatic Acute 1 H400 Chronic 1 H410; N-Nitrosodiphenylamine Nitrosamine Formation; ACGIH TLV-TWA 10 mg/m3; Azo Dye Intermediate (1987)","year":1987},{"id":"iarc_130_diphenylamine","type":"regulatory","title":"IARC Monographs Volume 130: Anthracene, 2-Bromopropane, Butyl Methacrylate, and Dimethyl Hydrogen Phosphite (and other agents) — Diphenylamine Group 2B (2021 evaluation, published 2022)","year":2022}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":48,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}