{"hq_id":"hq-c-org-000546","name":"Butyraldehyde","context":"human_adult","timestamp":"2026-10-27T21:03:29.673Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000546","sha256":"e13979c365608a7c34ec2096dec0d9f844322e1ae7adcd50098bd60e24b76818"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.410256,"weightedMean":0.410256,"std_dev":0.137365,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"IARC","year":2026,"value":0.5,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0.084233,"disagreement_magnitude":0.24952,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"butyraldehyde_regulatory_summary","type":"regulatory","title":"Butyraldehyde n-Butanal IARC Not Evaluated; EU CLP Flam Liq 3 H226 Flash Point -6C; Acute Tox 4 H302 H312 H332; No CMR Classification; FDA GRAS Fragrance Flavoring 21 CFR 172.515; Oxo Process Hydroformylation Propylene; 2-Ethylhexanol DEHP Plasticizer Precursor; ALDH Metabolism Butyric Acid SCFA HDAC Inhibitor; FEMA GRAS; Readily Biodegradable Not PBT","year":2023},{"id":"src_iarc_loc_d797_000546","type":"iarc","title":"IARC Monographs — List of Classifications: Butyraldehyde, Group 2B (Volume 141)","url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_261","type":"pubchem","title":"PubChem: Toxicity section (CID 261)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/261/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"pubchem-computed-cid-261","type":"database","title":"PubChem computed properties for CID 261 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/261"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC's List of Classifications DATA, as the IARC list page loads it","url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-261","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 261; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/261/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-261","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 261; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/261/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid8021513","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8021513 (Butyraldehyde)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8021513"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-261","type":"database","title":"PubChem computed structure descriptors for CID 261 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/261"},{"id":"r60-2026-10-18-a5oj-eu-cellar-32008r1272-oj","type":"regulatory","title":"Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008)","year":2008,"url":"https://publications.europa.eu/resource/celex/32008R1272"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":48,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}