{"hq_id":"hq-c-org-000536","name":"HMDI (bis(4-isocyanatocyclohexyl)methane)","context":"human_adult","timestamp":"2026-05-01T19:46:00.129Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US OSHA / ACGIH / EU REACH (HMDI — H12MDI — Desmodur W — methylene dicyclohexyl diisocyanate — CAS 5124-30-1 — aliphatic diisocyanate — ACGIH TLV-C: 0.005 ppm (ceiling) for isocyanate class — reflecting respiratory sensitization hazard; OSHA PEL: none specific for HMDI (TDI PEL 0.02 ppm); EU REACH: registered; EU CLP: Acute Tox. 4 (inhalation), Skin Irrit. 2, Eye Irrit. 2, Resp. Sens. 1, Skin Sens. 1 — H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled); H317 (May cause allergic skin reaction); SVHC candidate list: not listed (isocyanate respiratory sensitizers are hazardous but not SVHCs in EU REACH under current criteria); no IARC carcinogenicity classification; no NTP carcinogenicity listing; no US EPA carcinogenicity classification; NIOSH recommended limit: <0.005 ppm (ceiling) for all isocyanates; MDI (aromatic — hq-c-org-000074) differs from HMDI (aliphatic) in volatility but both are potent respiratory sensitizers; aliphatic diisocyanates used in light-stable non-yellowing polyurethane coatings; isocyanates collectively cause approximately 5–10% of all occupational asthma cases):no iarc, ntp, or epa carcinogenicity classificatio","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:US OSHA / ACGIH / EU REACH (HMDI — H12MDI — Desmodur W — methylene dicyclohexyl diisocyanate — CAS 5124-30-1 — aliphatic diisocyanate — ACGIH TLV-C: 0.005 ppm (ceiling) for isocyanate class — reflecting respiratory sensitization hazard; OSHA PEL: none specific for HMDI (TDI PEL 0.02 ppm); EU REACH: registered; EU CLP: Acute Tox. 4 (inhalation), Skin Irrit. 2, Eye Irrit. 2, Resp. Sens. 1, Skin Sens. 1 — H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled); H317 (May cause allergic skin reaction); SVHC candidate list: not listed (isocyanate respiratory sensitizers are hazardous but not SVHCs in EU REACH under current criteria); no IARC carcinogenicity classification; no NTP carcinogenicity listing; no US EPA carcinogenicity classification; NIOSH recommended limit: <0.005 ppm (ceiling) for all isocyanates; MDI (aromatic — hq-c-org-000074) differs from HMDI (aliphatic) in volatility but both are potent respiratory sensitizers; aliphatic diisocyanates used in light-stable non-yellowing polyurethane coatings; isocyanates collectively cause approximately 5–10% of all occupational asthma cases):no iarc, ntp, or epa carcinogenicity classificatio","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis"}