{"hq_id":"hq-c-org-000533","name":"Sorbitol (E420)","context":"human_adult","timestamp":"2026-08-28T02:50:41.471Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_efsa_sorbitol_2020","type":"regulatory","title":"FDA GRAS 21 CFR 184.1835 Sorbitol; EFSA E420 Re-evaluation 2019 ADI Not Specified; JECFA ADI Not Specified; Osmotic Laxative >50g/day; Contraindicated Hereditary Fructose Intolerance HFI Aldolase B; Hepatic Sorbitol Dehydrogenase Fructose Conversion; Toddler Diarrhea Apple Pear Juice Natural Sorbitol; 70% Solution Pharmaceutical Laxative; No IARC NTP EPA EFSA Carcinogenicity Classification","year":2020}],"sources_scope":"record","warnings":["unmapped_classification:US FDA:no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":44,"warnings":["unmapped_classification:US FDA:no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}