{"hq_id":"hq-c-org-000532","name":"Erythritol","context":"human_adult","timestamp":"2026-05-01T19:46:22.603Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Erythritol — E968 — FDA GRAS (21 CFR 184.1277 — affirmed GRAS as direct food additive; also multiple GRAS notices — GRN 000076 Nikken Chemicals; approximately zero-calorie sugar alcohol — 0.24 kcal/g vs 4 kcal/g sucrose); EFSA E968 opinion — ADI 'not specified' (2010 re-evaluation); WHO/JECFA: ADI 'not specified'; naturally occurring in small amounts in mushrooms, grapes, melons, fermented foods, human blood; commercially produced by fermentation of glucose using Moniliella pollinis or Candida magnoliae; approximately 70% sweetness of sucrose; minimal osmotic laxative effect at typical consumption levels (absorbed from small intestine — ~90% absorbed, excreted renally — distinguishes it from poorly absorbed sugar alcohols like sorbitol/mannitol); does not cause dental caries; 2023 Nature Medicine paper (Hazen et al.) reported epidemiological association between circulating erythritol levels and cardiovascular events (MACE) — correlation between endogenous erythritol and/or dietary erythritol intake and cardiovascular risk — findings require independent replication and regulatory bodies have not changed GRAS status; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":44,"warnings":["unmapped_classification:US FDA / EFSA (Erythritol — E968 — FDA GRAS (21 CFR 184.1277 — affirmed GRAS as direct food additive; also multiple GRAS notices — GRN 000076 Nikken Chemicals; approximately zero-calorie sugar alcohol — 0.24 kcal/g vs 4 kcal/g sucrose); EFSA E968 opinion — ADI 'not specified' (2010 re-evaluation); WHO/JECFA: ADI 'not specified'; naturally occurring in small amounts in mushrooms, grapes, melons, fermented foods, human blood; commercially produced by fermentation of glucose using Moniliella pollinis or Candida magnoliae; approximately 70% sweetness of sucrose; minimal osmotic laxative effect at typical consumption levels (absorbed from small intestine — ~90% absorbed, excreted renally — distinguishes it from poorly absorbed sugar alcohols like sorbitol/mannitol); does not cause dental caries; 2023 Nature Medicine paper (Hazen et al.) reported epidemiological association between circulating erythritol levels and cardiovascular events (MACE) — correlation between endogenous erythritol and/or dietary erythritol intake and cardiovascular risk — findings require independent replication and regulatory bodies have not changed GRAS status; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis"}