{"hq_id":"hq-c-org-000531","name":"Polydextrose (E1200)","context":"human_adult","timestamp":"2026-05-01T18:29:47.951Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Polydextrose — E1200 — FDA GRAS (21 CFR 172.841 — affirmed as GRAS as direct food additive at levels up to 90 g/day for adults and 45 g/day for children up to 12 years; labeling requirement: 'Sensitive individuals may experience a laxative effect from excessive consumption'); EFSA E1200 opinion — ADI 'not specified'; synthetic glucose polymer produced by condensation polymerization of glucose with sorbitol and citric acid at high temperature under vacuum; caloric value approximately 1 kcal/g (compared to 4 kcal/g for digestible carbohydrates); used as bulking agent, texturizer, fat replacer, dietary fiber; osmotic laxative effect above approximately 50 g/day; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; FDA classifies as soluble dietary fiber — qualifies for dietary fiber declaration on nutrition label since FDA's 2016 dietary fiber definition revision):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":24,"warnings":["unmapped_classification:US FDA / EFSA (Polydextrose — E1200 — FDA GRAS (21 CFR 172.841 — affirmed as GRAS as direct food additive at levels up to 90 g/day for adults and 45 g/day for children up to 12 years; labeling requirement: 'Sensitive individuals may experience a laxative effect from excessive consumption'); EFSA E1200 opinion — ADI 'not specified'; synthetic glucose polymer produced by condensation polymerization of glucose with sorbitol and citric acid at high temperature under vacuum; caloric value approximately 1 kcal/g (compared to 4 kcal/g for digestible carbohydrates); used as bulking agent, texturizer, fat replacer, dietary fiber; osmotic laxative effect above approximately 50 g/day; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; FDA classifies as soluble dietary fiber — qualifies for dietary fiber declaration on nutrition label since FDA's 2016 dietary fiber definition revision):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"]},"schema":"synthesis"}