{"hq_id":"hq-c-org-000529","name":"Guar Gum (E412)","context":"human_adult","timestamp":"2026-05-01T19:47:43.263Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Guar gum — E412 — FDA GRAS (21 CFR 184.1339 — affirmed as GRAS as direct human food ingredient; thickener, stabilizer, emulsifier); EFSA E412 re-evaluation 2017 — ADI 'not specified'; JECFA ADI 'not specified'; Codex INS 412; derived from the endosperm of guar beans (Cyamopsis tetragonoloba); galactomannan polysaccharide; occupational asthma from guar gum dust is a recognized health hazard in food and pharmaceutical manufacturing (IgE-mediated sensitization; occupational asthma cases documented; occupational exposure limits established in some jurisdictions); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; diet pill safety concern — FDA banned high-dose guar gum in diet pills in 1990 due to esophageal and gastrointestinal obstruction risk from rapid hydration; at food additive use levels no such risk; viscous fiber cholesterol-lowering evidence):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 9 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 9 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":26,"warnings":["unmapped_classification:US FDA / EFSA (Guar gum — E412 — FDA GRAS (21 CFR 184.1339 — affirmed as GRAS as direct human food ingredient; thickener, stabilizer, emulsifier); EFSA E412 re-evaluation 2017 — ADI 'not specified'; JECFA ADI 'not specified'; Codex INS 412; derived from the endosperm of guar beans (Cyamopsis tetragonoloba); galactomannan polysaccharide; occupational asthma from guar gum dust is a recognized health hazard in food and pharmaceutical manufacturing (IgE-mediated sensitization; occupational asthma cases documented; occupational exposure limits established in some jurisdictions); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; diet pill safety concern — FDA banned high-dose guar gum in diet pills in 1990 due to esophageal and gastrointestinal obstruction risk from rapid hydration; at food additive use levels no such risk; viscous fiber cholesterol-lowering evidence):no carcinogenicity classification; fda gras 21 cfr","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 9 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 9 positive"]},"schema":"synthesis"}