{"hq_id":"hq-c-org-000528","name":"Xanthan Gum (E415)","context":"human_adult","timestamp":"2026-05-01T19:34:00.274Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Xanthan gum — E415 — FDA GRAS (21 CFR 172.695 — thickener, emulsifier, stabilizer, foam enhancer; affirmed GRAS for direct use in food); EFSA E415 opinion — ADI 'not specified' (JECFA 1986 ADI not specified; reaffirmed by EFSA 2017 re-evaluation); fermentation-derived polysaccharide from Xanthomonas campestris; used as thickener, stabilizer, emulsifier, and texture modifier; dysphagia management: xanthan gum-based thickening products (SimplyThick) — contraindicated in premature neonates (necrotizing enterocolitis cases reported 2012; FDA safety alert); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA for xanthan gum itself; occupational inhalation allergy (xanthan gum dust) reported in food manufacturing workers; otherwise well-established food safety record):no carcinogenicity classification; fda gras 21 cfr","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":23,"warnings":["unmapped_classification:US FDA / EFSA (Xanthan gum — E415 — FDA GRAS (21 CFR 172.695 — thickener, emulsifier, stabilizer, foam enhancer; affirmed GRAS for direct use in food); EFSA E415 opinion — ADI 'not specified' (JECFA 1986 ADI not specified; reaffirmed by EFSA 2017 re-evaluation); fermentation-derived polysaccharide from Xanthomonas campestris; used as thickener, stabilizer, emulsifier, and texture modifier; dysphagia management: xanthan gum-based thickening products (SimplyThick) — contraindicated in premature neonates (necrotizing enterocolitis cases reported 2012; FDA safety alert); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA for xanthan gum itself; occupational inhalation allergy (xanthan gum dust) reported in food manufacturing workers; otherwise well-established food safety record):no carcinogenicity classification; fda gras 21 cfr"]},"schema":"synthesis"}