{"hq_id":"hq-c-org-000525","name":"Dimethicone (PDMS)","context":"human_adult","timestamp":"2026-05-01T19:53:48.818Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Dimethicone — polydimethylsiloxane; PDMS — FDA-approved OTC drug active ingredient (Category I skin protectant; anti-flatulence agent simethicone); FDA-approved pharmaceutical excipient (inactive ingredient database; oral, topical, ophthalmic routes); FDA food additive (21 CFR 173.340 — defoaming agent in food processing; 21 CFR 172.210 — coating for fresh fruits and vegetables; antifoaming agent in fermentation); EFSA E900 — ADI 'not specified' (1999 opinion reaffirmed); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA for fully polymerized PDMS; cyclomethicone (cyclic siloxane) impurities — particularly D4 (octamethylcyclotetrasiloxane) and D5 (decamethylcyclopentasiloxane) — classified as SVHC by ECHA under EU REACH (endocrine disrupting, persistent) and restricted in wash-off cosmetics (EU restriction D4/D5 ≥0.1% in rinse-off products); distinction between high-molecular-weight linear PDMS (dimethicone — very low risk) and cyclic siloxane impurities (D4/D5 — significant environmental concern) is critical):no carcinogenicity classification for fully polyme","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":24,"warnings":["unmapped_classification:US FDA / EFSA (Dimethicone — polydimethylsiloxane; PDMS — FDA-approved OTC drug active ingredient (Category I skin protectant; anti-flatulence agent simethicone); FDA-approved pharmaceutical excipient (inactive ingredient database; oral, topical, ophthalmic routes); FDA food additive (21 CFR 173.340 — defoaming agent in food processing; 21 CFR 172.210 — coating for fresh fruits and vegetables; antifoaming agent in fermentation); EFSA E900 — ADI 'not specified' (1999 opinion reaffirmed); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA for fully polymerized PDMS; cyclomethicone (cyclic siloxane) impurities — particularly D4 (octamethylcyclotetrasiloxane) and D5 (decamethylcyclopentasiloxane) — classified as SVHC by ECHA under EU REACH (endocrine disrupting, persistent) and restricted in wash-off cosmetics (EU restriction D4/D5 ≥0.1% in rinse-off products); distinction between high-molecular-weight linear PDMS (dimethicone — very low risk) and cyclic siloxane impurities (D4/D5 — significant environmental concern) is critical):no carcinogenicity classification for fully polyme"]},"schema":"synthesis"}