{"hq_id":"hq-c-org-000524","name":"Stearic Acid","context":"human_adult","timestamp":"2026-05-01T19:44:45.114Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Stearic acid — octadecanoic acid — FDA GRAS (21 CFR 184.1090 — direct human food ingredient, affirmed as GRAS; also 21 CFR 172.860 — fatty acids); FDA-approved pharmaceutical excipient (inactive ingredient database; oral, topical, vaginal routes — tablet lubricant, binder, coating component, cream/ointment ingredient); EFSA: stearic acid is an endogenous saturated fatty acid present in food; no specific numerical ADI — safety well-established from dietary exposure; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; neutral metabolic effects on LDL cholesterol distinguishing it from other saturated fatty acids; widely present in animal fats (beef tallow, cocoa butter) and some plant oils):no carcinogenicity classification; fda gras; fda-a","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":44,"warnings":["unmapped_classification:US FDA / EFSA (Stearic acid — octadecanoic acid — FDA GRAS (21 CFR 184.1090 — direct human food ingredient, affirmed as GRAS; also 21 CFR 172.860 — fatty acids); FDA-approved pharmaceutical excipient (inactive ingredient database; oral, topical, vaginal routes — tablet lubricant, binder, coating component, cream/ointment ingredient); EFSA: stearic acid is an endogenous saturated fatty acid present in food; no specific numerical ADI — safety well-established from dietary exposure; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; neutral metabolic effects on LDL cholesterol distinguishing it from other saturated fatty acids; widely present in animal fats (beef tallow, cocoa butter) and some plant oils):no carcinogenicity classification; fda gras; fda-a","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 3 positive"]},"schema":"synthesis"}