{"hq_id":"hq-c-org-000522","name":"Lanolin","context":"human_adult","timestamp":"2026-05-01T18:24:21.444Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (Lanolin — wool wax; wool grease — FDA-approved OTC drug active ingredient (skin protectant, nipple cream) and pharmaceutical excipient; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; well-documented contact sensitizer causing allergic contact dermatitis in approximately 1–3% of dermatology patch-test populations; historical concern about organophosphate and organochlorine pesticide residues (from sheep dip treatments) in lanolin from inadequately refined sources — pharmacopeial specification limits for pesticide residuals in pharmaceutical-grade lanolin (USP, BP); EU cosmetic regulations require lanolin purity specifications addressing pesticide contamination):no carcinogenicity classification; fda-approved ot","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":24,"warnings":["unmapped_classification:US FDA / EFSA (Lanolin — wool wax; wool grease — FDA-approved OTC drug active ingredient (skin protectant, nipple cream) and pharmaceutical excipient; no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; well-documented contact sensitizer causing allergic contact dermatitis in approximately 1–3% of dermatology patch-test populations; historical concern about organophosphate and organochlorine pesticide residues (from sheep dip treatments) in lanolin from inadequately refined sources — pharmacopeial specification limits for pesticide residuals in pharmaceutical-grade lanolin (USP, BP); EU cosmetic regulations require lanolin purity specifications addressing pesticide contamination):no carcinogenicity classification; fda-approved ot"]},"schema":"synthesis"}