{"hq_id":"hq-c-org-000519","name":"Hydroxypropyl methylcellulose (HPMC)","context":"human_adult","timestamp":"2026-05-01T19:47:20.113Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US FDA / EFSA (HPMC — hydroxypropyl methylcellulose; hypromellose — FDA GRAS (21 CFR 182.1480) and approved pharmaceutical excipient (USP/NF; inactive ingredient database); EFSA approved food additive E464 with no specified numerical ADI (acceptable daily intake 'not specified' = very low toxicity concern); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; chemically inert semisynthetic cellulose ether; not systemically absorbed from GI tract; used as tablet film coating, controlled-release matrix former, viscosity-increasing agent, and artificial tears/ophthalmic lubricant):no carcinogenicity classification; fda gras; efsa ","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":23,"warnings":["unmapped_classification:US FDA / EFSA (HPMC — hydroxypropyl methylcellulose; hypromellose — FDA GRAS (21 CFR 182.1480) and approved pharmaceutical excipient (USP/NF; inactive ingredient database); EFSA approved food additive E464 with no specified numerical ADI (acceptable daily intake 'not specified' = very low toxicity concern); no carcinogenicity classification by IARC, NTP, US EPA, or EFSA; chemically inert semisynthetic cellulose ether; not systemically absorbed from GI tract; used as tablet film coating, controlled-release matrix former, viscosity-increasing agent, and artificial tears/ophthalmic lubricant):no carcinogenicity classification; fda gras; efsa "]},"schema":"synthesis"}