{"hq_id":"hq-c-org-000516","name":"Isophorone","context":"human_adult","timestamp":"2026-08-28T02:52:46.450Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.401108,"weightedMean":0.401108,"std_dev":0.141025,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"US EPA","year":1989,"value":0.5,"weight":0.41},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":1989,"value":0.82,"weight":0.41},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":1989,"value":0.5,"weight":0.41},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":1989,"value":1,"weight":0.41},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":1989,"value":0.75,"weight":0.41},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.059833,"disagreement_magnitude":0.335052,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"usepa_iarc_isophorone_1989_group_c","type":"regulatory","title":"US EPA IRIS 1989 Isophorone Group C Possible Human Carcinogen RfD 0.2 mg/kg/day; CERCLA Hazardous Substance; Hepatotoxic Nephrotoxic High Doses Rodents; α,β-Unsaturated Ketone Skin Sensitizer; OSHA PEL 25 ppm; IPDI Polyurethane Precursor Solvent","year":1989}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}