{"hq_id":"hq-c-org-000516","name":"Isophorone","context":"human_adult","timestamp":"2026-05-01T19:46:44.597Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US EPA / IARC (Isophorone — 3,5,5-trimethyl-2-cyclohexen-1-one — US EPA Group C possible human carcinogen (1989 IRIS assessment, pre-2005 guidelines); IARC Group 3 — not classifiable as to carcinogenicity to humans (Vol 47, 1989); US EPA IRIS chronic oral RfD 0.2 mg/kg/day; CERCLA hazardous substance priority list; hepatotoxic and nephrotoxic at high doses in rodents; industrial ketone solvent for paints, lacquers, and coatings; detected in surface water and groundwater near industrial discharge sites; occupational inhalation limit OSHA PEL 25 ppm; not classified by NTP or EFSA for carcinogenicity):us epa group c possible human carcinogen (pre-2005","unmapped_classification:EPA CTX / IRIS:c (possible human carcinogen)","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group c possible human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:US EPA / IARC (Isophorone — 3,5,5-trimethyl-2-cyclohexen-1-one — US EPA Group C possible human carcinogen (1989 IRIS assessment, pre-2005 guidelines); IARC Group 3 — not classifiable as to carcinogenicity to humans (Vol 47, 1989); US EPA IRIS chronic oral RfD 0.2 mg/kg/day; CERCLA hazardous substance priority list; hepatotoxic and nephrotoxic at high doses in rodents; industrial ketone solvent for paints, lacquers, and coatings; detected in surface water and groundwater near industrial discharge sites; occupational inhalation limit OSHA PEL 25 ppm; not classified by NTP or EFSA for carcinogenicity):us epa group c possible human carcinogen (pre-2005","unmapped_classification:EPA CTX / IRIS:c (possible human carcinogen)","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / EPA OPP:group c possible human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive"]},"schema":"synthesis"}