{"hq_id":"hq-c-org-000515","name":"Methacrylic acid","context":"human_adult","timestamp":"2026-05-01T18:35:26.378Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:US EPA / OSHA (methacrylic acid — 2-methylacrylic acid — corrosive vinyl carboxylic acid; no carcinogenicity classification by IARC, NTP, US EPA IRIS, or EFSA; OSHA PEL 20 ppm (8-hour TWA); ACGIH TLV-C 20 ppm (ceiling); corrosive to skin, eyes, and respiratory mucosa; metabolized via β-oxidation to CO₂ and acetone; readily biodegrades in the environment; monomer for PMMA (Plexiglas/acrylic glass), hydrogel contact lenses (HEMA copolymers), dental resins, adhesives, and coatings; not classified for reproductive toxicity or endocrine disruption by IARC, NTP, ECHA, or EPA):no carcinogenicity classification; corrosive vinyl","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:US EPA / OSHA (methacrylic acid — 2-methylacrylic acid — corrosive vinyl carboxylic acid; no carcinogenicity classification by IARC, NTP, US EPA IRIS, or EFSA; OSHA PEL 20 ppm (8-hour TWA); ACGIH TLV-C 20 ppm (ceiling); corrosive to skin, eyes, and respiratory mucosa; metabolized via β-oxidation to CO₂ and acetone; readily biodegrades in the environment; monomer for PMMA (Plexiglas/acrylic glass), hydrogel contact lenses (HEMA copolymers), dental resins, adhesives, and coatings; not classified for reproductive toxicity or endocrine disruption by IARC, NTP, ECHA, or EPA):no carcinogenicity classification; corrosive vinyl","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis"}