{"hq_id":"hq-c-org-000506","name":"1,2-Butylene oxide","context":"human_adult","timestamp":"2026-05-01T19:16:01.111Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[],"warnings":["unmapped_classification:IARC (Group 3 — not classifiable as to its carcinogenicity to humans — Vol 97, 2008; 1,2-epoxybutane; occupational reactive monoepoxide; genotoxic in bacterial mutagenicity assays in vitro; inadequate evidence of carcinogenicity in humans and limited evidence in experimental animals; not classified for carcinogenicity by NTP, US EPA IRIS, or EFSA; occupational inhalation exposure concern during butylene oxide manufacturing and handling):iarc group 3 — not classifiable as to carcinogenic","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 18 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 18 positiv","single_source_warning"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:IARC (Group 3 — not classifiable as to its carcinogenicity to humans — Vol 97, 2008; 1,2-epoxybutane; occupational reactive monoepoxide; genotoxic in bacterial mutagenicity assays in vitro; inadequate evidence of carcinogenicity in humans and limited evidence in experimental animals; not classified for carcinogenicity by NTP, US EPA IRIS, or EFSA; occupational inhalation exposure concern during butylene oxide manufacturing and handling):iarc group 3 — not classifiable as to carcinogenic","unmapped_classification:EPA CTX / IARC:group 2b - possibly carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 18 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 18 positiv"]},"schema":"synthesis"}