{"hq_id":"hq-c-org-000489","name":"Testosterone","context":"human_adult","timestamp":"2026-10-27T18:50:34.777Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000489","sha256":"1669346af5c591186893e65f420944eb253caa34c2620fd0bfab8be4e07dd2e5"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.5636,"weightedMean":0.5636,"std_dev":0.258162,"confidence_interval_95":[0.2,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2012,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.379816,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_monograph_100a_androgens_2012","type":"regulatory","title":"IARC Monographs Supplement 7 (1987)","year":2012},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"iarc-list-of-classified-agents","type":"regulatory","title":"IARC: List of classifications (the list's data file)","year":2026,"url":"https://webapi.iarc.who.int/loc/loc.app.js"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-6013","type":"database","title":"PubChem computed properties for CID 6013 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6013"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-6013","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 6013; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6013/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-occupational-safety-and-health-administr-cid-6013","type":"database","title":"Occupational Safety and Health Administration (OSHA), as recorded by PubChem (Experimental Properties, CID 6013; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6013/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid8022371","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8022371 (Testosterone)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8022371"},{"id":"pubchem-computed-structure-cid-6013","type":"database","title":"PubChem computed structure descriptors for CID 6013 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6013"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}