{"hq_id":"hq-c-org-000475","name":"Succinylcholine","context":"human_adult","timestamp":"2026-10-27T18:50:03.233Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000475","sha256":"2dba9be4cda9a38f781eed53a43f810ba1dc7f1ee6a33a5fc6c4974aef9708a5"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_succinylcholine_black_box_pediatric_1994_updated","type":"regulatory","title":"FDA Succinylcholine Prescribing Information Black Box Pediatric Hyperkalemic Cardiac Arrest 2023: Duchenne DMD Undiagnosed Myopathy; RSI Emergency Airway Retained Use; Malignant Hyperthermia RYR1 Dantrolene Antidote; Pseudocholinesterase Deficiency Prolonged Paralysis","year":2023},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-computed-cid-22475","type":"database","title":"PubChem computed properties for CID 22475 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/22475"},{"id":"r60-2026-09-27-d901-partBCD-comptox-cas-hq-c-org-000475","type":"database","title":"D-901 AC1 part BCD capture: 2026-09-27-d901-partBCD-comptox-cas-hq-c-org-000475","url":"https://comptox.epa.gov/dashboard-api/ccdapp1/search/chemical/equal-with-detail/71-27-2"},{"id":"pubchem-exp-cameo-chemicals-cid-22475","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 22475; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/22475/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid1023603","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1023603 (Succinylcholine)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1023603"},{"id":"pubchem-computed-structure-cid-22475","type":"database","title":"PubChem computed structure descriptors for CID 22475 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/22475"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US FDA (approved drug; non-scheduled):no carcinogenicity classification; fda-approved de","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:US FDA (approved drug; non-scheduled):no carcinogenicity classification; fda-approved de"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}