{"hq_id":"hq-c-org-000461","name":"Benzophenone","context":"human_adult","timestamp":"2026-08-28T02:41:07.885Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.519334,"weightedMean":0.519334,"std_dev":0.195935,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2013,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2013,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2013,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2013,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_vol101_benzophenone_2013","type":"iarc_monograph","title":"IARC Monographs Vol 101 (2013): Benzophenone Group 2B Possibly Carcinogenic; Renal Tubular Cell Tumors Male Rat NTP Bioassay; Food Contact Material Migration UV Photoinitiator; ERα Estrogenic Activity","year":2013},{"id":"fda_benzophenone_gras_revocation_2013","type":"regulatory","title":"FDA Benzophenone GRAS Status Revocation 2013: No Longer Generally Recognized as Safe Food Additive; IARC 2B Classification Basis; Specific Migration Limit EU 10 μg/kg Food; Octocrylene Degradation Product","year":2013}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":45,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}