{"hq_id":"hq-c-org-000445","name":"Retinoic acid (tretinoin)","context":"human_adult","timestamp":"2026-08-28T01:29:13.253Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_tretinoin_2000","type":"regulatory","title":"US EPA Retinoic Acid/Tretinoin: Group D Not Classifiable Carcinogen; FDA Pregnancy Category X Confirmed Human Teratogen; Retinoid Embryopathy; Prescription Acne and Photoaging Drug; APL Differentiation Therapy; Topical Systemic Absorption Low; iPLEDGE Program Isotretinoin","year":2000},{"id":"efsa_sccs_tretinoin_2010","type":"regulatory","title":"EFSA/SCCS Retinoic Acid: Prohibited in EU Cosmetics; Vitamin A Precursor Limits for Cosmetics; Retinoid Embryopathy Craniofacial Cardiac CNS; Retinoic Acid Receptor Hox Gene Disruption; Aquatic Endocrine Disruption Fish Larvae; Surface Water Detection Post-WWTP","year":2010}],"sources_scope":"record","warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not classifiable for carcinogenicity as consumer p","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not classifiable for carcinogenicity as consumer p","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_pregnant","aquatic_life","human_teen","human_elderly","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}