{"hq_id":"hq-c-org-000443","name":"Methylisothiazolinone (MIT)","context":"human_adult","timestamp":"2026-08-28T02:54:05.569Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_mit_2000","type":"regulatory","title":"US EPA Methylisothiazolinone: Group D Not Classifiable; FIFRA Pesticide Registration; Strong Sensitizer EC3 0.5–1%; Paraben-Free Preservative Epidemic; Wet Wipes Sensitization; In Vitro Neurotoxicity; Industrial Paint and Adhesive Biocide","year":2000},{"id":"efsa_sccs_mit_2016","type":"regulatory","title":"EFSA/SCCS Methylisothiazolinone: EU Leave-On Ban Commission Regulation 2016/1198; SCCS 2014 Safety Assessment; Rinse-Off Maximum 0.0015%; Pediatric Wet Wipes Dermatitis Epidemic; Diaper Area ACD; Aquatic LC50 0.1–2 mg/L","year":2016}],"sources_scope":"record","warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; strong contact ","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion - category 1b (sco","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitisation - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2b (category 1b) (scor","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EU SCCS:not safe for use in leave-on cosmetics at any conc","unmapped_classification:EU CLP:acute tox 3 (oral), acute tox 3 (dermal), skin cor","unmapped_classification:EU Cosmetics:banned in leave-on cosmetics (2015). allowed in ri","unmapped_classification:ACDS:contact allergen of the year 2013 (american contac","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; strong contact ","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion - category 1b (sco","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitisation - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 8.2b (category 1b) (scor","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EU SCCS:not safe for use in leave-on cosmetics at any conc","unmapped_classification:EU CLP:acute tox 3 (oral), acute tox 3 (dermal), skin cor","unmapped_classification:EU Cosmetics:banned in leave-on cosmetics (2015). allowed in ri","unmapped_classification:ACDS:contact allergen of the year 2013 (american contac"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}