{"hq_id":"hq-c-org-000442","name":"Methylchloroisothiazolinone (MCI/Kathon CG)","context":"human_adult","timestamp":"2026-10-27T20:02:59.557Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000442","sha256":"04f34cb7bd9e01deb6847fd3b31598788276f2cad42eb2a3867445579a46859c"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_mci_2000","type":"regulatory","title":"US EPA Methylchloroisothiazolinone: Group D Not Classifiable; FIFRA Registered Antimicrobial Pesticide; Extreme Skin Sensitizer EC3 ~0.002%; Kathon CG Industrial Biocide; Aquatic LC50 0.1–1 mg/L; Algal EC50 0.02–0.05 mg/L","year":2000},{"id":"efsa_sccs_mci_2014","type":"regulatory","title":"EFSA/SCCS MCI/Kathon CG: EU Leave-On Cosmetics Ban 2015; Rinse-Off Maximum 0.0015%; Contact Sensitization Epidemic Europe 1980s–2010s; LLNA Extreme Sensitizer; Sensitization Rate Reversal Post-Restriction; Wet Wipes MI Cross-Reaction","year":2014},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02009R1223-20260518","type":"regulatory","title":"Consolidated TEXT: 32009R1223 — EN — 18.05.2026","url":"https://publications.europa.eu/resource/celex/02009R1223-20260518"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-33344","type":"database","title":"PubChem computed properties for CID 33344 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/33344"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-33344","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 33344; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/33344/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid9034286","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9034286 (Methylchloroisothiazolinone (MCI/Kathon CG))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9034286"},{"id":"pubchem-computed-structure-cid-33344","type":"database","title":"PubChem computed structure descriptors for CID 33344 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/33344"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; regulated as po","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin irritation: skin corrosion - category 1b (sco","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2b (category 1b) (scor","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":48,"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; regulated as po","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin irritation: skin corrosion - category 1b (sco","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2b (category 1b) (scor","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}