{"hq_id":"hq-c-org-000440","name":"DMDM hydantoin","context":"human_adult","timestamp":"2026-10-27T19:07:28.041Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000440","sha256":"cba74b7d2e57ed63d6c1490ffe7d9cf626c0b1f6fc847793796d5c1e2a17d9b9"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_dmdm_2000","type":"regulatory","title":"US EPA DMDM Hydantoin: Group D Not Classifiable Carcinogen; Formaldehyde-Releasing Preservative; Contact Sensitizer; Cumulative Formaldehyde Exposure; FDA 2024 Proposed Cosmetic Restriction; Patch Test Positivity 1–4%","year":2000},{"id":"efsa_sccs_dmdm_2010","type":"regulatory","title":"EFSA/SCCS DMDM Hydantoin: EU Cosmetics Regulation Annex V Permitted Preservative; Maximum 1% (as formaldehyde equivalent); Mandatory Labeling >0.05% Free Formaldehyde; Contact Sensitization Critical Endpoint; REACH Restriction Review","year":2010},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02009R1223-20260518","type":"regulatory","title":"Consolidated TEXT: 32009R1223 — EN — 18.05.2026","url":"https://publications.europa.eu/resource/celex/02009R1223-20260518"},{"id":"r60-2026-09-28-d899-s3-b04-cellar-32022R1181","type":"regulatory","title":"L_2022184EN.01000301.xml","url":"https://publications.europa.eu/resource/celex/32022R1181"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_22947","type":"pubchem","title":"PubChem: Toxicity section (CID 22947)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/22947/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-22947","type":"database","title":"PubChem computed properties for CID 22947 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/22947"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid8035217","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID8035217 (DMDM hydantoin)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID8035217"},{"id":"pubchem-computed-structure-cid-22947","type":"database","title":"PubChem computed structure descriptors for CID 22947 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/22947"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; contact sensiti","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin irritation: skinirr2 (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: moderate or mild irritati","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:US EPA:not classifiable as to human carcinogenicity (grou","unmapped_classification:EFSA:not evaluated for carcinogenicity; contact sensiti","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin irritation: skinirr2 (score: high)","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3b (category 3) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: moderate or mild irritati","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}