{"hq_id":"hq-c-org-000438","name":"2,4-Diaminotoluene (toluene-2,4-diamine; TDA)","context":"human_adult","timestamp":"2026-10-27T18:50:44.542Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000438","sha256":"8e90e6c4b1ea555a880dd066eb5aaf6cf2b0aacf31984bce5c237d85f94938da"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.65903,"weightedMean":0.65903,"std_dev":0.106693,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.288713,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_tda_vol16_1978","type":"iarc_monograph","title":"IARC Monographs Volume 16: Some Aromatic Amines and Related Nitro Compounds — Hair Dyes, Colouring Agents, and Miscellaneous Industrial Chemicals — 2,4-Diaminotoluene Group 2B; Hepatocellular Carcinomas in Rats; Hair Dye Withdrawal 1970s; TDI Manufacturing Intermediate; DNT Anaerobic Degradation Product","year":1978},{"id":"epa_tda_2000","type":"regulatory","title":"US EPA 2,4-Diaminotoluene: Group B2 Probable Carcinogen; Military Range Contaminant from DNT/TNT Reduction; Aquatic Chronic NOEC 0.1–1 mg/L; Hepatotoxic Diamine; Historical Hair Dye Component; Sediment Screening Benchmark","year":2000},{"id":"r60-2026-09-25-d897-niosh-npg-npgd0620","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Toluenediamine","url":"https://www.cdc.gov/niosh/npg/npgd0620.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1915-subpartZ","type":"regulatory","title":"Subpart Z—Toxic and Hazardous Substances","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1915&subpart=Z"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-7261","type":"database","title":"PubChem computed properties for CID 7261 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7261"},{"id":"src_pubchem_tox_7261","type":"pubchem","title":"PubChem: Toxicity section (CID 7261)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7261/JSON?heading=Toxicity"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-exp-cameo-chemicals-cid-7261","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 7261; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7261/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-7261","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 7261; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7261/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-7261","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 7261; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7261/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid4020402","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4020402 (2,4-Diaminotoluene (toluene-2,4-diamine; TDA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4020402"},{"id":"pubchem-computed-structure-cid-7261","type":"database","title":"PubChem computed structure descriptors for CID 7261 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7261"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (llna): low to moderat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":49,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (llna): low to moderat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: studies indicate no sign"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_pregnant"]}