{"hq_id":"hq-c-org-000438","name":"2,4-Diaminotoluene (toluene-2,4-diamine; TDA)","context":"human_adult","timestamp":"2026-08-28T01:30:55.489Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.65903,"weightedMean":0.65903,"std_dev":0.106693,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1978,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1978,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1978,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1978,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1978,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.288713,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_tda_vol16_1978","type":"iarc_monograph","title":"IARC Monographs Volume 16: Some Aromatic Amines and Related Nitro Compounds — Hair Dyes, Colouring Agents, and Miscellaneous Industrial Chemicals — 2,4-Diaminotoluene Group 2B; Hepatocellular Carcinomas in Rats; Hair Dye Withdrawal 1970s; TDI Manufacturing Intermediate; DNT Anaerobic Degradation Product","year":1978},{"id":"epa_tda_2000","type":"regulatory","title":"US EPA 2,4-Diaminotoluene: Group B2 Probable Carcinogen; Military Range Contaminant from DNT/TNT Reduction; Aquatic Chronic NOEC 0.1–1 mg/L; Hepatotoxic Diamine; Historical Hair Dye Component; Sediment Screening Benchmark","year":2000}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): low to moderat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":46,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): low to moderat","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_pregnant"]}