{"hq_id":"hq-c-org-000436","name":"2,4-Dinitrotoluene (2,4-DNT)","context":"human_adult","timestamp":"2026-10-27T19:58:55.182Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000436","sha256":"05c74a89139c1f393bc1823de733a5f5f510a7426849fb9c7fc8657a2038a8c4"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.660881,"weightedMean":0.660881,"std_dev":0.117035,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1996,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1996,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1996,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1996,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1996,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.219767,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dnt_vol65_1996","type":"iarc_monograph","title":"IARC Monographs Volume 65: Printing Processes and Printing Inks, Carbon Black and Some Nitro Compounds — 2,4-Dinitrotoluene Group 2B; Hepatocellular Carcinomas in Rodents; TDI Manufacturing Intermediate; Methemoglobin Former; Male Reproductive Toxicant","year":1996},{"id":"epa_dnt_2000","type":"regulatory","title":"US EPA 2,4-Dinitrotoluene: Group B2 Probable Carcinogen; Military Range Groundwater Contaminant; Methemoglobinemia; Superfund Priority Compound; Aquatic Chronic Criterion 0.11 mg/L; TDA Anaerobic Degradation Product","year":2000},{"id":"r60-2026-09-25-d897-niosh-npg-npgd0235","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Dinitrotoluene","url":"https://www.cdc.gov/niosh/npg/npgd0235.html"},{"id":"r60-2026-09-25-d867-ecfr-29cfr1926-subpartD","type":"regulatory","title":"Subpart D—Occupational Health and Environmental Controls","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-29.xml?part=1926&subpart=D"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-23-eu-reach-consolidated-02006R1907-20260622","type":"regulatory","title":"Consolidated TEXT: 32006R1907 — EN — 22.06.2026","url":"https://publications.europa.eu/resource/celex/02006R1907-20260622"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"src_pubchem_tox_8461","type":"pubchem","title":"PubChem: Toxicity section (CID 8461)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8461/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp109-pdf","type":"assessment","title":"Toxicological Profile for Dinitrotoluenes (ATSDR, February 2016)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp109.pdf"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0524-summary-pdf","type":"assessment","title":"2,4-Dinitrotoluene: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0524_summary.pdf"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-8461","type":"database","title":"PubChem computed properties for CID 8461 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8461"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-cameo-chemicals-cid-8461","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 8461; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8461/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-8461","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 8461; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/8461/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0020529","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0020529 (2,4-Dinitrotoluene (2,4-DNT))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0020529"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-8461","type":"database","title":"PubChem computed structure descriptors for CID 8461 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/8461"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 3 (score: moderate)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":54,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 3 (score: moderate)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_pregnant"]}