{"hq_id":"hq-c-org-000427","name":"Melphalan","context":"human_adult","timestamp":"2026-05-01T18:28:30.318Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.800329,"weightedMean":0.800329,"std_dev":0.161993,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.339684,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["Failed to vectorize source EPA CTX / NTP RoC: Source must have year field","Failed to vectorize source EPA CTX / CalEPA: Source must have year field","unmapped_classification:US EPA:carcinogenic to humans","unmapped_classification:EPA CTX / IARC:group 1 - carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skinirr2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","limited_synthesis"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":2,"db_version":44,"warnings":["Failed to vectorize source EPA CTX / NTP RoC: Source must have year field","Failed to vectorize source EPA CTX / CalEPA: Source must have year field","unmapped_classification:US EPA:carcinogenic to humans","unmapped_classification:EPA CTX / IARC:group 1 - carcinogenic to humans","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 20 positiv","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skinirr2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)"]},"schema":"synthesis"}