{"hq_id":"hq-c-org-000423","name":"o-Anisidine","context":"human_adult","timestamp":"2026-08-28T02:50:04.445Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.650995,"weightedMean":0.650995,"std_dev":0.156456,"confidence_interval_95":[0.65,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"IARC","year":2021,"value":0.7,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41},{"source":"US EPA","year":2000,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"US EPA","year":2000,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41},{"source":"US EPA","year":2000,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41},{"source":"US EPA","year":2000,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.344616,"warning":null},"outliers":[{"source":"HQ_DIRECT","value":0.35}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_oanisidine_vol73_1999","type":"iarc_monograph","title":"IARC Monographs Volume 73: Some Chemicals That Cause Tumours of the Kidney or Urinary Bladder in Rodents — the 1999 o-anisidine evaluation, superseded by Volume 127 (2020 evaluation); Bladder Transitional Cell Carcinoma in Rats; Methemoglobin Formation; CYP Metabolism; Dye/Pigment Intermediate (1999)","year":1999},{"id":"epa_oanisidine_2000","type":"regulatory","title":"US EPA o-Anisidine Assessment: Group B2 Probable Carcinogen; OSHA PEL 0.5 mg/m³ Skin Notation; Azo Dye Manufacturing Intermediate; Methemoglobinemia Acute Toxicity; Cancer Slope Factor; Dermal Absorption Concern","year":2000},{"id":"iarc_127_oanisidine","type":"iarc_monograph","title":"IARC Monographs Volume 127: Some Aromatic Amines and Related Compounds — ortho-Anisidine Group 2A (2020 evaluation, published 2021)","year":2021}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 6 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 6 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): ambiguous (sco"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":49,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 6 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 6 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): ambiguous (sco"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_pregnant"]}