{"hq_id":"hq-c-org-000422","name":"Captafol","context":"human_adult","timestamp":"2026-10-27T18:11:36.820Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000422","sha256":"c3843a41ff09fd2517d688630cbcb4c5ef7e51236ca6ad2f3037c4fc07d4ca36"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.705265,"weightedMean":0.705265,"std_dev":0.06154,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1999,"value":0.75,"weight":0.41},{"source":"IARC","year":1991,"value":0.7,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1991,"value":0.82,"weight":0.41},{"source":"US EPA","year":1999,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1991,"value":0.5,"weight":0.41},{"source":"US EPA","year":1999,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1991,"value":1,"weight":0.41},{"source":"US EPA","year":1999,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1991,"value":0.75,"weight":0.41},{"source":"US EPA","year":1999,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.589733,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_captafol_vol53_1987","type":"iarc_monograph","title":"IARC Monographs Volume 53: Occupational Exposures in Insecticide Application — Captafol Group 2A; NCI Bioassay Duodenal Adenocarcinomas in Mice; Renal Tubular Tumors in Rats; Thiol-Reactive Fungicide; Contact Sensitization","year":1987,"url":"http://publications.iarc.fr/71"},{"id":"epa_captafol_cancellation_1999","type":"regulatory","title":"US EPA Captafol Cancellation 1987–1999: Group B2 Probable Carcinogen; FQPA Safety Factor; Food Crop Tolerance Cancellation; Rotterdam Convention PIC Listing; Allergic Contact Dermatitis; Fish Acute Toxicity","year":1999},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"src_pubchem_tox_17038","type":"pubchem","title":"PubChem: Toxicity section (CID 17038)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/17038/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0098","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Captafol","url":"https://www.cdc.gov/niosh/npg/npgd0098.html"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0216-summary-pdf","type":"assessment","title":"IRIS Chemical Assessment Summary: Captafol; CASRN 2425-06-1","url":"https://iris.epa.gov/static/pdfs/0216_summary.pdf"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-cameo-chemicals-cid-17038","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 17038; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/17038/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid4020242","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID4020242 (Captafol)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID4020242"},{"id":"pubchem-computed-structure-cid-17038","type":"database","title":"PubChem computed structure descriptors for CID 17038 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/17038"},{"id":"r60-2026-10-18-a5oj-eu-cellar-32008r1272-oj","type":"regulatory","title":"Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008)","year":2008,"url":"https://publications.europa.eu/resource/celex/32008R1272"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2a (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":51,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2a (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_pregnant"]}