{"hq_id":"hq-c-org-000421","name":"Furfuryl alcohol","context":"human_adult","timestamp":"2026-08-28T02:42:50.885Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.525838,"weightedMean":0.525838,"std_dev":0.152106,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"IARC","year":1995,"value":0.5,"weight":0.41},{"source":"US EPA","year":1995,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1995,"value":0.82,"weight":0.41},{"source":"US EPA","year":1995,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1995,"value":0.5,"weight":0.41},{"source":"US EPA","year":1995,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1995,"value":1,"weight":0.41},{"source":"US EPA","year":1995,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1995,"value":0.75,"weight":0.41},{"source":"US EPA","year":1995,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_furfurylalcohol_vol63_1995","type":"iarc_monograph","title":"IARC Monographs Volume 63: Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals — Furfuryl Alcohol Group 2B; Nasal Tumors in Rats; Mouse Liver Tumors; Coffee and Roasted Food Source; Foundry Furan Resins","year":1995},{"id":"efsa_furfurylalcohol_2011","type":"regulatory","title":"EFSA Scientific Opinion on Furfuryl Alcohol in Food — Genotoxic Carcinogen; MOE Approach; Coffee and Bread Dietary Exposure; Foundry Worker Occupational Exposure; OSHA PEL 50 ppm; EU Flavoring Restriction","year":2011}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irritation - category 2a (scor","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitisation - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): low to moderat"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":47,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irritation - category 2a (scor","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitisation - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): low to moderat"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}