{"hq_id":"hq-c-org-000412","name":"4,4'-Methylenedianiline (MDA)","context":"human_adult","timestamp":"2026-10-27T17:01:32.619Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000412","sha256":"6a7ae45b37adac403334bab4f02706c19e5911cd4583ea55b86ac14c42ce7ba1"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.604759,"weightedMean":0.604759,"std_dev":0.164488,"confidence_interval_95":[0.35,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1988,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":1988,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":1988,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":1988,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":1988,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_mda_vol39_1986","type":"iarc_monograph","title":"IARC Monographs Volume 39: 4,4'-Methylenedianiline (MDA) — Group 2B; Hepatocellular Carcinomas and Thyroid Tumors in Rodents; Epping Jaundice Hepatotoxicity; MDI Precursor","year":1986},{"id":"kopelman_epping_jaundice_1966","type":"study","title":"Kopelman et al.: Epping Jaundice — Hepatitis from MDA-Contaminated Flour; 84 Cases; Cholestatic Pattern; Dose-Response; First Evidence of MDA Human Hepatotoxicity","year":1966},{"id":"osha_mda_standard","type":"regulatory","title":"OSHA Standard 29 CFR 1910.1050: 4,4'-Methylenedianiline — PEL 0.01 ppm; Carcinogen Designation; Skin Absorption; Medical Surveillance; Epoxy Curing Industry Requirements","year":1992},{"id":"r60-2026-09-23-eu-reach-consolidated-02006R1907-20260622","type":"regulatory","title":"Consolidated TEXT: 32006R1907 — EN — 22.06.2026","url":"https://publications.europa.eu/resource/celex/02006R1907-20260622"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_7577","type":"pubchem","title":"PubChem: Toxicity section (CID 7577)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7577/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-09-30-d899-s1-b08-niosh-npg-npgd0415-4-4-methylenedianiline","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards: 4,4'-Methylenedianiline (npgd0415)","url":"https://www.cdc.gov/niosh/npg/npgd0415.html"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp122-pdf","type":"assessment","title":"Toxicological Profile for Methylenedianiline (ATSDR, August 1998)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp122.pdf"},{"id":"pubchem-computed-cid-7577","type":"database","title":"PubChem computed properties for CID 7577 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7577"},{"id":"pubchem-exp-cameo-chemicals-cid-7577","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 7577; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7577/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-7577","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 7577; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7577/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-occupational-safety-and-health-administr-cid-7577","type":"database","title":"Occupational Safety and Health Administration (OSHA), as recorded by PubChem (Experimental Properties, CID 7577; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7577/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid6022422","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID6022422 (4,4'-Methylenedianiline (MDA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID6022422"},{"id":"pubchem-computed-structure-cid-7577","type":"database","title":"PubChem computed structure descriptors for CID 7577 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/7577"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): high frequ","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":48,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Germany, as recorded by ToxValDB:skin sensitization: sh (score: high)","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): high frequ","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: studies indicate no signi"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","aquatic_life","human_teen","human_elderly","human_pregnant"]}