{"hq_id":"hq-c-org-000410","name":"4-Chloro-o-toluidine","context":"human_adult","timestamp":"2026-08-28T04:02:03.124Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.705265,"weightedMean":0.705265,"std_dev":0.06154,"confidence_interval_95":[0.65,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2010,"value":0.75,"weight":0.41},{"source":"IARC","year":2010,"value":0.7,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2010,"value":0.82,"weight":0.41},{"source":"US EPA","year":2010,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2010,"value":0.5,"weight":0.41},{"source":"US EPA","year":2010,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2010,"value":1,"weight":0.41},{"source":"US EPA","year":2010,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2010,"value":0.75,"weight":0.41},{"source":"US EPA","year":2010,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.589733,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_coot_vol99_2010","type":"iarc_monograph","title":"IARC Monographs Volume 99 (2010): 4-Chloro-o-Toluidine — Group 2A (probably carcinogenic to humans); Bladder Cancer in German Chemical Plant Workers; Chlordimeform Manufacturing Cohort; Aromatic Amine Mechanism","year":2010,"url":"https://www.ncbi.nlm.nih.gov/books/NBK390838/"},{"id":"stasik_coot_bladder_1988","type":"study","title":"Stasik: Carcinoma of the Urinary Bladder in a 4-Chloro-o-Toluidine Cohort — Key Epidemiological Study; German Chemical Manufacturing Workers; Bladder Cancer Excess","year":1988},{"id":"reach_coot_restriction","type":"regulatory","title":"ECHA REACH Restriction: 4-Chloro-o-Toluidine in Textile Articles — Aromatic Amine Bladder Carcinogen; Concentration Limits; Azo Dye Cleavage Products; EU Textile Regulations","year":2014}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":47,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (single report) (ames: none","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skinsens1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","aquatic_life","human_teen","human_elderly","human_pregnant"]}