{"hq_id":"hq-c-org-000409","name":"o-Toluidine (2-methylaniline)","context":"human_adult","timestamp":"2026-08-28T01:29:09.229Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.797089,"weightedMean":0.797089,"std_dev":0.110635,"confidence_interval_95":[0.75,0.95],"source_positions":[{"source":"IARC","year":2010,"value":0.95,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.85,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2010,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2010,"value":0.82,"weight":0.41},{"source":"US EPA","year":2010,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2010,"value":0.5,"weight":0.41},{"source":"US EPA","year":2010,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2010,"value":1,"weight":0.41},{"source":"US EPA","year":2010,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2010,"value":0.75,"weight":0.41},{"source":"US EPA","year":2010,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.262433,"disagreement_magnitude":0.339684,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_otoluidine_vol99_2010","type":"iarc_monograph","title":"IARC Monographs Volume 99: o-Toluidine — Group 1; Bladder Cancer in Goodyear Niagara Falls Rubber Chemical Workers; Reclassification from 2A; N-Hydroxylation Mechanism","year":2010,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304426/"},{"id":"hayes_goodyear_cohort","type":"study","title":"Ward EM et al. (1996): Monitoring of aromatic-amine exposures in workers at a chemical plant with a known bladder-cancer excess (J Natl Cancer Inst; Goodyear Niagara Falls cohort). PMID 8683635","year":1996,"url":"https://pubmed.ncbi.nlm.nih.gov/8683635/"},{"id":"niosh_otoluidine_hazard","type":"regulatory","title":"NIOSH Alert: Preventing Bladder Cancer from Exposure to o-Toluidine and Aniline (DHHS/NIOSH Pub. 90-116)","year":1990,"url":"https://www.cdc.gov/niosh/docs/90-116/default.html"}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: severe irritation (score"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":49,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 14 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: severe irritation (score"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","aquatic_life","human_teen","human_elderly","human_pregnant"]}