{"hq_id":"hq-c-org-000407","name":"1,2-Dibromo-3-chloropropane (DBCP)","context":"human_adult","timestamp":"2026-08-28T02:46:38.846Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.65903,"weightedMean":0.65903,"std_dev":0.106693,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1985,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1979,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1979,"value":0.82,"weight":0.41},{"source":"US EPA","year":1985,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1979,"value":0.5,"weight":0.41},{"source":"US EPA","year":1985,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1979,"value":1,"weight":0.41},{"source":"US EPA","year":1985,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1979,"value":0.75,"weight":0.41},{"source":"US EPA","year":1985,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.288713,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dbcp_vol20_1979","type":"iarc_monograph","title":"IARC Monographs Volume 20: DBCP — Group 2B; Multiple Rodent Tumor Types; Male Reproductive Toxicity; Germinal Epithelium Depletion; Agricultural Exposure Data","year":1979},{"id":"whorton_dbcp_workers_1977","type":"study","title":"Whorton et al.: Infertility in Male Pesticide Workers — DBCP Azoospermia Discovery at Occidental Chemical Lathrop; Landmark Occupational Reproductive Toxicology Study","year":1977},{"id":"epa_dbcp_mcl_groundwater","type":"regulatory","title":"US EPA: DBCP MCL 0.0002 mg/L; Emergency Suspension 1977; California Groundwater Contamination; San Joaquin Valley Agricultural Legacy; Carcinogenic Risk Assessment","year":1991}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":47,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 15 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: serious eye damage/eye irritation ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant"]}