{"hq_id":"hq-c-org-000405","name":"Propylene oxide","context":"human_adult","timestamp":"2026-08-28T02:45:53.107Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.604759,"weightedMean":0.604759,"std_dev":0.164488,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2001,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1994,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1994,"value":0.82,"weight":0.41},{"source":"US EPA","year":2001,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1994,"value":0.5,"weight":0.41},{"source":"US EPA","year":2001,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1994,"value":1,"weight":0.41},{"source":"US EPA","year":2001,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1994,"value":0.75,"weight":0.41},{"source":"US EPA","year":2001,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_po_vol60_1994","type":"iarc_monograph","title":"IARC Monographs Volume 60: Propylene Oxide — Group 2B; Nasal Cavity Carcinomas in Rats and Mice; Inadequate Human Evidence; Direct-Acting Epoxide Alkylation","year":1994},{"id":"epa_po_iris_2001","type":"regulatory","title":"US EPA IRIS: Propylene Oxide — Likely Human Carcinogen via Inhalation; Nasal Cavity Tumor Dose-Response; Inhalation Unit Risk Estimate; Occupational and Food Fumigation Exposure","year":2001},{"id":"ntp_po_14th_ror","type":"regulatory","title":"NTP 14th Report on Carcinogens: Propylene Oxide — Reasonably Anticipated to Be a Human Carcinogen; Rodent Inhalation Data; Polyurethane Foam and Food Fumigation Industry Exposure","year":2016}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 19 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 19 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":46,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 19 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 19 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: sh (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_ingestion","exposure_ocular","occupational_exposure"]}