{"hq_id":"hq-c-org-000404","name":"Dimethyl sulfate","context":"human_adult","timestamp":"2026-10-27T17:01:44.922Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000404","sha256":"25f80c70690f5af6018459100a50a7fc111affa57ce37225494ae266d6008f78"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.705265,"weightedMean":0.705265,"std_dev":0.06154,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"IARC","year":1999,"value":0.7,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"US EPA","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"US EPA","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.589733,"disagreement_magnitude":0.308845,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (63th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dms_vol4_1974","type":"iarc_monograph","title":"IARC Monographs Volume 4 / Supplement 7: Dimethyl Sulfate — Group 2A; Local and Systemic Tumors in Rodents; Potent Alkylating Agent; Limited Human Epidemiology","year":1974,"url":"http://publications.iarc.fr/22 + key 2026-10-02-d-955-s36-d955-s36-iarc-vol4-landing (direction neutral) ; STOP (1) link row (named-unlinked"},{"id":"niosh_dms_occupational","type":"regulatory","title":"NIOSH: Dimethyl Sulfate — REL 0.1 ppm; Vesicant; Delayed Pulmonary Edema; Carcinogen Designation; Emergency Response Guidelines","year":1976},{"id":"atsdr_dms_toxprofile","type":"regulatory","title":"ATSDR Toxicological Profile: Dimethyl Sulfate — Acute Fatality Risk, Delayed Onset Toxicity, DNA Methylation Mechanism, Occupational Case Reports, Emergency Planning","year":1992},{"id":"r60-2026-09-29-d899-s1-b07-niosh-npg-npgd0229-dimethyl-sulfate","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Dimethyl sulfate","url":"https://www.cdc.gov/niosh/npg/npgd0229.html"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1 | Occupational Safety and Health Administration","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-09-30-d918-iris-landing-365-dimethyl-sulfate","type":"regulatory","title":"Dimethyl sulfate | CASRN 77-78-1 | DTXSID5024055 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=365"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"pubchem-computed-cid-6497","type":"database","title":"PubChem computed properties for CID 6497 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6497"},{"id":"src_pubchem_tox_6497","type":"pubchem","title":"PubChem: Toxicity section (CID 6497)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6497/JSON?heading=Toxicity"},{"id":"pubchem-exp-cameo-chemicals-cid-6497","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 6497; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6497/JSON?heading=Experimental+Properties"},{"id":"r60-2026-09-27-d867-cc1-ich-m7-r2-addendum-pdftotext","type":"regulatory","title":"Application of the principles of the ICH M7 guideline to calculation of compound-specific acceptable intakes: Addendum to M7(R2) (final version, adopted 3 April 2023)","url":"https://database.ich.org/sites/default/files/ICH_M7(R2)_Addendum_Step4_2023_0216.pdf"},{"id":"ctx_pred_dtxsid5024055","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID5024055 (Dimethyl sulfate)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID5024055"},{"id":"pubchem-computed-structure-cid-6497","type":"database","title":"PubChem computed structure descriptors for CID 6497 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6497"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1a-1c (score: very high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2c (category 1c) (scor","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (llna): high frequency","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: corrosive (score: very h"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":49,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1a-1c (score: very high)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2c (category 1c) (scor","unmapped_classification:New Zealand, as recorded by ToxValDB:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (llna): high frequency","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: corrosive (score: very h"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_dermal","human_teen","human_elderly","human_pregnant"]}