{"hq_id":"hq-c-org-000402","name":"Methyl isocyanate (MIC)","context":"human_adult","timestamp":"2026-10-27T18:00:34.287Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000402","sha256":"da9df94e96c719a0f093503dc07baa4697020e727f36fd40c989148ffe249297"}]},"risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.925,"weightedMean":0.925,"std_dev":0,"confidence_interval_95":[0.925,0.925],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.925,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates extreme risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"icmr_bhopal_health_studies","type":"study","title":"Indian Council of Medical Research: Health Effects of the Bhopal Gas Tragedy — Mortality Data, Pulmonary Effects, Reproductive Outcomes, Neurological Effects, Long-term Survivor Cohort","year":2004,"url":"https://www.icmr.gov.in/icmrobject/custom_data/1720337800_bhopal_gas_report.pdf"},{"id":"atsdr_mic_toxprofile","type":"regulatory","title":"ATSDR Medical Management Guidelines: Methyl Isocyanate -- Bhopal Disaster Review, Acute Pulmonary Toxicity, Ocular Effects, Chronic Health Effects, Exposure Limits (document-type corrected: no dedicated ATSDR \"Toxicological Profile\" exists for methyl isocyanate specifically -- ATSDR's in-depth profiles cover other isocyanates, e.g. HDI/TDI/MDI; the actual MIC document is the Medical Management Guidelines)","year":2002,"url":"https://wwwn.cdc.gov/tsp/mmg/mmgdetails.aspx?mmgid=628&toxid=116"},{"id":"dhara_bhopal_chronic_2002","type":"study","title":"Dhara & Dhara: The Union Carbide Disaster in Bhopal — A Review of Health Effects — International Journal of Occupational and Environmental Health; Long-term Epidemiology, Reproductive Effects, Immune Dysregulation","year":2002,"url":"https://pubmed.ncbi.nlm.nih.gov/12641179/"},{"id":"niosh_mic_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Methyl isocyanate (CAS 624-83-9)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0423.html"},{"id":"osha_mic_pel","type":"regulatory","title":"OSHA PEL — Methyl isocyanate (29 CFR 1910.1000 Table Z-1)","year":2020,"url":"https://www.osha.gov/chemicaldata/450"},{"id":"epa_mic_aegl","type":"regulatory","title":"EPA Acute Exposure Guideline Levels (AEGL) — Methyl isocyanate","year":2010,"url":"https://www.epa.gov/aegl/methyl-isocyanate-results-aegl-program"},{"id":"mukherjee_bhopal_2008","type":"study","title":"Mishra PK, Samarth RM, Pathak N, Jain SK, Banerjee S, Maudar KK. Bhopal Gas Tragedy: review of clinical and experimental findings after 25 years. International Journal of Occupational Medicine and Environmental Health (2009) -- author/citation corrected: no real \"Mukherjee 2008\" paper matching this claim could be located after an extensive multi-angle search (PubMed author search, Google Scholar-style queries); the topically-identical claim (chronic respiratory/ocular morbidity, 25 years post-disaster) is this real, verified paper","year":2009,"url":"https://pubmed.ncbi.nlm.nih.gov/19819837/"},{"id":"r60-2026-09-29-d899-s1-b07-niosh-idlh-profile-2017-105-methyl-isocyanate","type":"regulatory","title":"Immediately Dangerous to Life or Health (IDLH) Value Profile: Methyl Isocyanate | Publications | CDC","url":"https://www.cdc.gov/niosh/publications/numbered/2017-105.html"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"src_pubchem_tox_12228","type":"pubchem","title":"PubChem: Toxicity section (CID 12228)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/12228/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d907-f1d6179110","type":"regulatory","title":"Industry Code of Practice on Chemicals Classification and Hazard Communication (DOSH Malaysia)","url":"https://dosh.gov.my/wp-content/uploads/2026/06/ICOP-Chemical-Classification-and-Hazard-Communication-2014.pdf"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-03-d928-cellar-02009l0161-20180821","type":"regulatory","title":"Consolidated TEXT: 32009L0161 — EN — 21.08.2018","url":"https://publications.europa.eu/resource/celex/02009L0161-20180821"},{"id":"pubchem-computed-cid-12228","type":"database","title":"PubChem computed properties for CID 12228 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/12228"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-cameo-chemicals-cid-12228","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 12228; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/12228/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid1023786","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1023786 (Methyl isocyanate (MIC))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1023786"},{"id":"pubchem-computed-structure-cid-12228","type":"database","title":"PubChem computed structure descriptors for CID 12228 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/12228"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye dam. 1","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":51,"warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:ECHA (CLP Annex VI):eye irritation: eye dam. 1","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin irrit. 2","unmapped_classification:ECHA (CLP Annex VI):skin sensitization: skin sens. 1","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)","unmapped_classification:DOSH Malaysia (ICOP):eye irritation: eye dam. 1","unmapped_classification:DOSH Malaysia (ICOP):skin irritation: skin irrit. 2","unmapped_classification:DOSH Malaysia (ICOP):skin sensitization: skin sens. 1"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","human_child","exposure_dermal","exposure_ingestion","dog","cat","human_teen","human_elderly","human_infant","human_pregnant","exposure_ocular","occupational_exposure"]}