{"hq_id":"hq-c-org-000402","name":"Methyl isocyanate (MIC)","context":"human_adult","timestamp":"2026-08-28T02:46:24.858Z","risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.925,"weightedMean":0.925,"std_dev":0,"confidence_interval_95":[0.925,0.925],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.925,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"icmr_bhopal_health_studies","type":"study","title":"Indian Council of Medical Research: Health Effects of the Bhopal Gas Tragedy — Mortality Data, Pulmonary Effects, Reproductive Outcomes, Neurological Effects, Long-term Survivor Cohort","year":2004,"url":"https://www.icmr.gov.in/icmrobject/custom_data/1720337800_bhopal_gas_report.pdf"},{"id":"atsdr_mic_toxprofile","type":"regulatory","title":"ATSDR Medical Management Guidelines: Methyl Isocyanate -- Bhopal Disaster Review, Acute Pulmonary Toxicity, Ocular Effects, Chronic Health Effects, Exposure Limits (document-type corrected: no dedicated ATSDR \"Toxicological Profile\" exists for methyl isocyanate specifically -- ATSDR's in-depth profiles cover other isocyanates, e.g. HDI/TDI/MDI; the actual MIC document is the Medical Management Guidelines)","year":2002,"url":"https://wwwn.cdc.gov/tsp/mmg/mmgdetails.aspx?mmgid=628&toxid=116"},{"id":"dhara_bhopal_chronic_2002","type":"study","title":"Dhara & Dhara: The Union Carbide Disaster in Bhopal — A Review of Health Effects — International Journal of Occupational and Environmental Health; Long-term Epidemiology, Reproductive Effects, Immune Dysregulation","year":2002,"url":"https://pubmed.ncbi.nlm.nih.gov/12641179/"},{"id":"niosh_mic_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Methyl isocyanate (CAS 624-83-9)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0423.html"},{"id":"osha_mic_pel","type":"regulatory","title":"OSHA PEL — Methyl isocyanate (29 CFR 1910.1000 Table Z-1)","year":2020,"url":"https://www.osha.gov/chemicaldata/450"},{"id":"epa_mic_aegl","type":"regulatory","title":"EPA Acute Exposure Guideline Levels (AEGL) — Methyl isocyanate","year":2010,"url":"https://www.epa.gov/aegl/methyl-isocyanate-results-aegl-program"},{"id":"mukherjee_bhopal_2008","type":"study","title":"Mishra PK, Samarth RM, Pathak N, Jain SK, Banerjee S, Maudar KK. Bhopal Gas Tragedy: review of clinical and experimental findings after 25 years. International Journal of Occupational Medicine and Environmental Health (2009) -- author/citation corrected: no real \"Mukherjee 2008\" paper matching this claim could be located after an extensive multi-angle search (PubMed author search, Google Scholar-style queries); the topically-identical claim (chronic respiratory/ocular morbidity, 25 years post-disaster) is this real, verified paper","year":2009,"url":"https://pubmed.ncbi.nlm.nih.gov/19819837/"}],"sources_scope":"record","warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","human_child","exposure_dermal","exposure_ingestion","dog","cat","human_teen","human_elderly","human_infant","human_pregnant","exposure_ocular","occupational_exposure"]}