{"hq_id":"hq-c-org-000400","name":"Methoxychlor","context":"human_adult","timestamp":"2026-10-27T20:53:46.107Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000400","sha256":"98ff533c3b219321bb576f9c8103004caa4633e4679d30881bd711907328dc1c"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_methoxychlor_cancellation_2003","type":"regulatory","title":"US EPA Methoxychlor Voluntary Cancellation — Endocrine Disruption Concerns, HPTE Estrogenic Metabolite, Registration Review Decision, 2003","year":2003},{"id":"atsdr_methoxychlor_toxprofile","type":"regulatory","title":"ATSDR Toxicological Profile: Methoxychlor — Estrogenic Activity, Reproductive Toxicity, Endocrine Disruption, Aquatic Toxicity, Environmental Fate","year":2002},{"id":"skinner_methoxychlor_epigenetic","type":"study","title":"Skinner et al.: Transgenerational Epigenetic Actions of Methoxychlor — Altered DNA Methylation in Reproductive Tissues, Multi-generational Effects, Endocrine Disruption Mechanism","year":2005},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-25-d449-iris-369","type":"regulatory","title":"Methoxychlor | CASRN 72-43-5 | DTXSID9020827 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=369"},{"id":"r60-2026-10-03-d923-niosh-npgd0388","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Methoxychlor","url":"https://www.cdc.gov/niosh/npg/npgd0388.html"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"pubchem-computed-cid-4115","type":"database","title":"PubChem computed properties for CID 4115 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/4115"},{"id":"src_pubchem_tox_4115","type":"pubchem","title":"PubChem: Toxicity section (CID 4115)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/4115/JSON?heading=Toxicity"},{"id":"doc-2026-10-02-dd43f-doe-wildlife-benchmarks-tm86r3","type":"study","title":"ES/ER/TM-86/R3 Toxicological Benchmarks for Wildlife: 1996 Revision (DOE/ORNL)","url":"https://rais.ornl.gov/documents/tm86r3.pdf"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0369-summary-pdf","type":"assessment","title":"Methoxychlor; CASRN 72-43-5: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0369_summary.pdf"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-4115","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 4115; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/4115/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-4115","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 4115; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/4115/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-4115","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 4115; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/4115/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid9020827","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9020827 (Methoxychlor)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9020827"},{"id":"pubchem-computed-structure-cid-4115","type":"database","title":"PubChem computed structure descriptors for CID 4115 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/4115"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:EDC Assessment:endocrine disruptor","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Denmark, as recorded by ToxValDB:skin irritation: skinirr2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":50,"warnings":["unmapped_classification:EDC Assessment:endocrine disruptor","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IRIS:d (not classifiable as to human carcinogenicity)","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:EPA IRIS:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Denmark, as recorded by ToxValDB:skin irritation: skinirr2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant"]}