{"hq_id":"hq-c-org-000399","name":"β-HCH (beta-hexachlorocyclohexane)","context":"human_adult","timestamp":"2026-10-27T18:08:09.213Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000399","sha256":"abc81a9068f38790d03a10d904399e147070dd36c6cfa58008b4a7a9af45502e"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.527778,"weightedMean":0.527778,"std_dev":0.181923,"confidence_interval_95":[0.3,0.75],"source_positions":[{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2008,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_beta_hch_vol41","type":"iarc_monograph","title":"IARC Monographs Volume 41 / Supplement 7: β-HCH — Group 2B; animal carcinogenicity data; classified alongside α-HCH and γ-HCH isomers","year":1987},{"id":"stockholm_hch_annex_2009","type":"regulatory","title":"Stockholm Convention COP4: α-HCH and β-HCH Added to Annex A (Elimination) — HCH Waste Disposal Legacy, Breast Milk Monitoring, Global Persistence Data","year":2009},{"id":"who_human_milk_hch_monitoring","type":"regulatory","title":"WHO/UNEP Global Survey on Persistent Organic Pollutants in Human Milk — β-HCH as Dominant HCH Isomer in Breast Milk; South and East Asian Exposure Patterns; Declining Trends in Developed Countries","year":2007},{"id":"r60-2026-09-30-d918-iris-landing-244-beta-hexachlorocyclohexane-beta-hch","type":"regulatory","title":"beta-Hexachlorocyclohexane (beta-HCH) | CASRN 319-85-7 | DTXSID7020685 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=244"},{"id":"src_pubchem_tox_727","type":"pubchem","title":"PubChem: Toxicity section (CID 727)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/727/JSON?heading=Toxicity"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp43-pdf","type":"assessment","title":"Toxicological Profile for Hexachlorocyclohexane (HCH) (ATSDR, March 2024)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp43.pdf"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-computed-cid-727","type":"database","title":"PubChem computed properties for CID 727 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/727"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid7020685","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7020685 (β-HCH (beta-hexachlorocyclohexane))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7020685"}],"sources_scope":"record","derived_markers":[],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}