{"hq_id":"hq-c-org-000399","name":"β-HCH (beta-hexachlorocyclohexane)","context":"human_adult","timestamp":"2026-08-28T04:00:21.786Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.527778,"weightedMean":0.527778,"std_dev":0.181923,"confidence_interval_95":[0.5,0.75],"source_positions":[{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41}]},"recency":{"mean":0.649573,"weightedMean":0.649573,"std_dev":0.228942,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2008,"value":1,"weight":0.41}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_beta_hch_vol41","type":"iarc_monograph","title":"IARC Monographs Volume 41 / Supplement 7: β-HCH — Group 2B; animal carcinogenicity data; classified alongside α-HCH and γ-HCH isomers","year":1987},{"id":"stockholm_hch_annex_2009","type":"regulatory","title":"Stockholm Convention COP4: α-HCH and β-HCH Added to Annex A (Elimination) — HCH Waste Disposal Legacy, Breast Milk Monitoring, Global Persistence Data","year":2009},{"id":"who_human_milk_hch_monitoring","type":"regulatory","title":"WHO/UNEP Global Survey on Persistent Organic Pollutants in Human Milk — β-HCH as Dominant HCH Isomer in Breast Milk; South and East Asian Exposure Patterns; Declining Trends in Developed Countries","year":2007}],"sources_scope":"record","meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":43},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}