{"hq_id":"hq-c-org-000398","name":"Hexachlorobutadiene (HCBD)","context":"human_adult","timestamp":"2026-10-27T20:52:16.072Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000398","sha256":"b21384171e0cbd1f7ba2f99bc30bcf60a025e9fb61dd532bd429375956286c3d"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.535816,"weightedMean":0.535816,"std_dev":0.178081,"confidence_interval_95":[0.35,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_hcbd_vol73","type":"iarc_monograph","title":"IARC Monographs Volume 73: Hexachlorobutadiene — Group 3 (not classifiable); renal tubular tumors in rats; glutathione conjugation nephrotoxicity mechanism; industrial byproduct formation","year":1999},{"id":"stockholm_hcbd_annex_2015","type":"regulatory","title":"Stockholm Convention: HCBD Listed under Annex A (Elimination; decision SC-7/12) and Annex C (Unintentional Release Reduction; decision SC-8/12) — Chlorinated Solvent Manufacturing Byproduct Controls","year":2015},{"id":"atsdr_hcbd_minimal_risk","type":"regulatory","title":"ATSDR Minimal Risk Levels: Hexachlorobutadiene — Renal Toxicity as Primary Endpoint, Biomonitoring Data, Industrial Site Contamination, Aquatic Benchmarks","year":2008},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-30-d918-iris-landing-58-hexachlorobutadiene","type":"regulatory","title":"Hexachlorobutadiene | CASRN 87-68-3 | DTXSID7020683 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=58"},{"id":"src_pubchem_tox_6901","type":"pubchem","title":"PubChem: Toxicity section (CID 6901)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6901/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0314","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Hexachlorobutadiene","url":"https://www.cdc.gov/niosh/npg/npgd0314.html"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp42-pdf","type":"assessment","title":"Toxicological Profile for Hexachlorobutadiene (ATSDR, March 2021)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp42.pdf"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"pubchem-exp-cameo-chemicals-cid-6901","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 6901; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6901/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-6901","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 6901; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6901/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-6901","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 6901; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6901/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid7020683","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7020683 (Hexachlorobutadiene (HCBD))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7020683"},{"id":"pubchem-computed-structure-cid-6901","type":"database","title":"PubChem computed structure descriptors for CID 6901 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/6901"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:IARC:group 3 — not classifiable as to its carcinogenici","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":50,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:IARC:group 3 — not classifiable as to its carcinogenici","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Canada, as recorded by ToxValDB:skin sensitization: skin sensitization - category ","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: category 1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant"]}