{"hq_id":"hq-c-org-000398","name":"Hexachlorobutadiene (HCBD)","context":"human_adult","timestamp":"2026-08-28T02:48:07.002Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.456194,"weightedMean":0.456194,"std_dev":0.198232,"confidence_interval_95":[0.35,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35},{"source":"IARC","year":1999,"value":0.25,"weight":0.41}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"US EPA","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"US EPA","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"US EPA","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"US EPA","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.310258,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_hcbd_vol73","type":"iarc_monograph","title":"IARC Monographs Volume 73: Hexachlorobutadiene — Group 3 (not classifiable); renal tubular tumors in rats; glutathione conjugation nephrotoxicity mechanism; industrial byproduct formation","year":1999},{"id":"stockholm_hcbd_annex_2015","type":"regulatory","title":"Stockholm Convention COP7: HCBD Listed under Annex A (Elimination) and Annex C (Unintentional Release Reduction) — Chlorinated Solvent Manufacturing Byproduct Controls","year":2015},{"id":"atsdr_hcbd_minimal_risk","type":"regulatory","title":"ATSDR Minimal Risk Levels: Hexachlorobutadiene — Renal Toxicity as Primary Endpoint, Biomonitoring Data, Industrial Site Contamination, Aquatic Benchmarks","year":2008}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":47,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sensitization - category ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant"]}