{"hq_id":"hq-c-org-000397","name":"p,p'-DDE (dichlorodiphenyldichloroethylene)","context":"human_adult","timestamp":"2026-10-27T17:00:51.621Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000397","sha256":"a6885c40d5bf05f12d450f981a880a7278e7e8c32a06fa6d3b1975a1e001356f"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.615872,"weightedMean":0.615872,"std_dev":0.222424,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":2008,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.367097,"warning":null},"outliers":[{"source":"HQ_DIRECT","value":0.3}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_dde_vol53","type":"iarc_monograph","title":"IARC Monographs Volume 53: p,p'-DDE — Group 2B; animal carcinogenicity data; inadequate human evidence; DDT metabolite persistence; wildlife eggshell thinning mechanism","year":1991},{"id":"epa_dde_iris","type":"regulatory","title":"US EPA IRIS: DDT/DDE/DDD — Cancer Classification Likely Human Carcinogen; Biomonitoring Data; Anti-androgenic Mechanism; Fish Consumption Guidelines","year":2000},{"id":"nhanes_dde_monitoring","type":"regulatory","title":"CDC NHANES: Serum DDE Biomonitoring in the US Population — Near-Universal Exposure, Declining Trend Post-DDT Ban, Racial and Geographic Disparities, Association with DDT Malaria Control Regions","year":2019},{"id":"atsdr_ddt_dde_ddd_profile","type":"regulatory","title":"ATSDR Toxicological Profile for DDT, DDE, and DDD (CERCLA Substance Priority List top-15; lipophilic-bioaccumulation framework + breast-milk + adipose + serum-half-life + maternal-fetal-transfer cohort framework + decades-long elimination)","year":2022},{"id":"stockholm_ddt_annex_b_2004","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants (POPs): Text and Annexes, revised in 2025","year":2025},{"id":"niosh_ddt_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — DDT (parent compound; REL 0.5 mg/m³ TWA; 'Ca' carcinogen designation; cohort framework extends to DDE metabolite via half-life kinetics)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0174.html"},{"id":"cohn_dde_breast_cancer_2007","type":"study","title":"Cohn BA, Wolff MS, Cirillo PM, Sholtz RI — DDT and breast cancer in young women: new data on the significance of age at exposure (canonical CHDS California cohort framework driving IARC-113 estrogen-receptor + endocrine-disruptor pathway)","year":2007},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-25-d449-iris-328","type":"regulatory","title":"p,p'-Dichlorodiphenyldichloroethylene (DDE) | CASRN 72-55-9 | DTXSID9020374 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=328"},{"id":"src_pubchem_tox_3035","type":"pubchem","title":"PubChem: Toxicity section (CID 3035)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3035/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"pubchem-exp-cameo-chemicals-cid-3035","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 3035; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3035/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-3035","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 3035; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3035/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-3035","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 3035; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3035/JSON?heading=Experimental+Properties"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp35-pdf","type":"assessment","title":"Toxicological Profile for DDT, DDE, and DDD (ATSDR, April 2022)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp35.pdf"},{"id":"ctx_pred_dtxsid9020374","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9020374 (p,p'-DDE (dichlorodiphenyldichloroethylene))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9020374"},{"id":"pubchem-computed-structure-cid-3035","type":"database","title":"PubChem computed structure descriptors for CID 3035 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3035"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":49,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}