{"hq_id":"hq-c-org-000396","name":"Chlordecone (Kepone)","context":"human_adult","timestamp":"2026-08-29T03:23:44.100Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.65903,"weightedMean":0.65903,"std_dev":0.106693,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1979,"value":0.5,"weight":0.41}]},"confidence":{"mean":0.756849,"weightedMean":0.756849,"std_dev":0.127359,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1979,"value":0.82,"weight":0.41},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.553755,"weightedMean":0.553755,"std_dev":0.228859,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1979,"value":0.5,"weight":0.41},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.940796,"weightedMean":0.940796,"std_dev":0.119399,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1979,"value":1,"weight":0.41},{"source":"US EPA","year":2008,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.783549,"weightedMean":0.783549,"std_dev":0.067659,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1979,"value":0.75,"weight":0.41},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.288713,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_chlordecone_vol20","type":"iarc_monograph","title":"IARC Monographs Volume 20: Chlordecone (Kepone) — Group 2B; hepatocellular carcinomas in mice; inadequate human carcinogenicity evidence; Hopewell worker episode data","year":1979},{"id":"epa_kepone_hopewell_1975","type":"regulatory","title":"US EPA: James River/Chesapeake Bay Kepone Contamination — Worker Neurotoxicity, Fishing Ban 1975–1988, Aquatic Toxicity Assessment, Point Source Remediation","year":1976},{"id":"french_caribbean_chlordecone_plan","type":"regulatory","title":"French Ministry of Health: Chlordécone Plan — Martinique and Guadeloupe Contamination Assessment, Food Exposure, TIMOUN Birth Cohort, Prostate Cancer Risk, Soil Remediation Research","year":2008},{"id":"stockholm_chlordecone_annex_a_2009","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants — Chlordecone Annex A listing (eliminated globally; COP-4 Geneva 2009; canonical POPs designation framework alongside lindane + alpha-HCH + beta-HCH + pentachlorobenzene)","year":2009},{"id":"niosh_chlordecone_pocket_guide","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards — Chlordecone (REL 0.001 mg/m³ TWA; 'Ca' carcinogen designation; Hopewell-Virginia 1975 LSP-manufacturing-incident cohort framework)","year":2019},{"id":"atsdr_mirex_chlordecone_profile","type":"regulatory","title":"ATSDR Toxicological Profile for Mirex and Chlordecone (CERCLA Substance Priority List; James River + Lake Onondaga sediment-contamination + bioaccumulation + biomagnification cohort framework)","year":1995}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":48,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}